Molecular Mechanisms in General Anaesthesia

Molecular mechanisms of general anesthesia

General anesthetics produce a widespread neurodepression in the central nervous system by enhancing inhibitory neurotransmission and reducing excitatory neurotransmission. However, the action mechanisms of general anesthetics are not completely understood. Moreover, the general anesthetic state comprises multiple components (amnesia, unconsciousness, analgesia, and immobility), each of which is...

General Anaesthesia in Cattle

General anaesthesia is the controlled and reversible loss of consciousness, which is helpful in ruminants for many surgical procedures that warrant effective control of pain and movement. General anaesthesia is indicated when the demands of technical and anatomical aspects of surgical procedure exceed the capabilities of sedative drugs and local analgesia. Moreover, the patient co-operation and...

Which molecular targets are most relevant to general anaesthesia?

1. In view of the large number of possible molecular targets of general anaesthetics, it is necessary to have some criteria for judging which targets are important for producing general anaesthesia and which are probably not. 2. We consider in detail two criteria: sensitivity to clinically relevant concentrations of anaesthetics and stereoselectivity to anaesthetic optical isomers. 3. The targe...

General anesthetics and molecular mechanisms of unconsciousness.

The term ‘‘anesthesia’’ was originally used by the ancient Greek surgeon Dioscorides and resurrected by Dr Oliver Wendell Holmes to describe the insensible state produced by inhalation of ether. The goals of general anesthesia include amnesia, unconsciousness (also termed hypnosis), and immobilization. By definition, general anesthetics reversibly produce all 3 of these therapeutic effects. Gen...

Cerebral Oximetry in General Anaesthesia.